I hadn't thought about it until now, but my adblocker filters out and protects me from malicious content a staggering amount more than any anti-virus software.
I generally keep up with patching, good digital security, and news about exploits and zero-days. So, even on the Windows machines I run AV on I haven't had anything but false positives in ... I honestly can't remember.
If I ever saw a process acting suspect with network traffic or resource usage I would probably just restore from a backup.
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